Notch & Mastermind
Targeting in Cancer
The 11th International Conference. 28–30 September 2026.
Grecian Park Hotel, Konnos Bay, Cyprus
Keynote Sessions
Hear insights from world-leading experts on Notch–Mastermind signaling in cancer.
Open-Air Workshops
Gain practical knowledge through collaborative workshops by the Mediterranean.
Networking
Build valuable connections with researchers, clinicians, and industry leaders.
About the Conference
Organisers: Professors Agamemnon Epenetos, Imperial College London, UK, Martin Baron, University of Manchester, UK, Christina Kousparou, European University of Cyprus, Cyprus
Crystal structure of activated Notch, CSL and MAML
The Notch signaling pathway and MAML co-activators play central roles in cancer development and progression. Notch signaling is highly context-dependent and regulates critical cellular fate decisions, proliferation, and differentiation. Dysregulation of this pathway contributes to oncogenesis across multiple malignancies.
Ligand binding triggers a series of proteolytic cleavages, NICD nuclear translocation, and gene activation. Multiple nodes in this pathway are targetable, including ligand interactions, NRR stabilization, post-translational modifications, cleavage events, trafficking mechanisms, and protein-protein interactions.
MAML proteins scaffold the NICD–CSL complex and recruit co-activators; without MAML, transcription terminates. Notch hyperactivation can drive proliferation, impaired differentiation, apoptosis resistance, tumor microenvironment interactions, and cancer stem cell maintenance. In some tissue contexts, Notch may be tumor-suppressive, suggesting potential reactivation strategies.
Conference Objectives:
- Discuss mechanisms and regulation of the Notch–Mastermind pathway in cancer
- Present advances in targeting and reactivating Notch signaling therapeutically
- Foster networking and collaboration among researchers
- Explore new approaches and emerging therapeutic strategies
Featured Speakers
Martin Baron
University of Manchester, UK
Developing a synthetic lethal approach to target Notch-driven cancers.
Freddy Radtke
EPFL SV ISREC UPRAD, Switzerland
Novel Therapeutic Strategies Targeting Notch1–Myc–Driven T-Cell Acute Lymphoblastic Leukaemia
Rob Clarke
University of Manchester, UK
TBA
Anna Bigas
TBA
Notch in the induction of a stem cell dormancy program
Diana Bellavia
TBA
Non-canonical Notch pathways in solid tumors
Andreas Fisher
TBA
Endothelial Notch1 signaling in immunosuppression, metastasis, and cachexia
Joanna Kałafut
Lluis Espinosa's post doc
The Role of NOTCH3 in the regulation of cellular quiescence in Colorectal Cancer
Marc Voijis
TBA
New Notch regulators
Nancy Papalopulu
TBA
TBA
Antonio Maraver
TBA
TBA
Thomas Vaccari
TBA
TBA
Kim Dale (or post doc)
TBA
TBA
Keith Brennan
TBA
TBA
Agamemnon Epenetos
Anastasis Biotec Limited
Development of Dominant Negative Mastermind/ Notch therapeutics
Provisional Programme
28 Sep 2026
Why Attend
Cutting-Edge Mechanisms
Explore the latest discoveries in Notch pathway regulation, from ligand interactions to nuclear transcription. Learn about novel targetable nodes and regulatory mechanisms.
Therapeutic Advances
Discover innovative strategies for targeting Notch-driven cancers and reactivating tumor-suppressive Notch signaling. Hear about clinical developments and preclinical breakthroughs.
Networking & Collaboration
Connect with leading researchers, clinicians, and industry experts. Build collaborations during workshops, poster sessions, and social events in an intimate conference setting.
Stunning Cyprus Venue
Experience world-class science at the beautiful Grecian Park Hotel in Konnos Bay. Enjoy Mediterranean sunshine, crystalline waters, and sunset networking by the sea.
Venue & Travel
Grecian Park Hotel
Located in the stunning Konnos Bay, Cyprus, Grecian Park Hotel offers world-class facilities with breathtaking Mediterranean views. The venue provides an ideal environment for scientific discussion and networking.
Discounted rates available for conference attendees booking between 8 Sep – 5 Oct 2026
Book AccommodationRegistration
Secure your place at this landmark conference. Early bird rates available until 30 April 2026.
Early Bird
Valid until 30 April 2026
- ✓All conference sessions
- ✓Welcome reception
- ✓Conference dinner
- ✓Coffee breaks & lunch
- ✓Workshop access
- ✓Certificate of attendance
Standard
Standard registration
- ✓All conference sessions
- ✓Welcome reception
- ✓Conference dinner
- ✓Coffee breaks & lunch
- ✓Workshop access
- ✓Certificate of attendance
Student
Student rate with valid ID
- ✓All conference sessions
- ✓Welcome reception
- ✓Coffee breaks & lunch
- ✓Workshop access
- ✓Certificate of attendance
- ✓Certificate of attendance
Poster Submissions
We welcome poster submissions on all aspects of Notch and Mastermind targeting in cancer. Selected posters will be featured in brief oral presentations.
Please submit your posters ASAP
Submit PosterFAQ
Join Us in Cyprus
Be part of the leading international conference on Notch and Mastermind targeting in cancer. Network with experts, discover breakthrough research, and enjoy Mediterranean hospitality.